One Case of Blood Pressure Increase and Body Shivering Induced by Injection of Urinary Kallidinogenase
10.3870/j.issn.1004-0781.2025.10.026
- VernacularTitle:注射用尤瑞克林致血压升高伴寒战1例
- Author:
Kexin WANG
1
;
Erxia SHI
1
;
Zhongyan ZHOU
1
Author Information
1. 呼和浩特市第一医院药剂科,呼和浩特 010030
- Publication Type:Journal Article
- Keywords:
Injection of urinary kallidinogenase;
Elevated blood pressure;
Chills;
Adverse drug reactions
- From:
Herald of Medicine
2025;44(10):1678-1680
- CountryChina
- Language:Chinese
-
Abstract:
Objective To introduce a case of elevated blood pressure with chills caused by Urinary Kallidinogenase.Methods The diagnosis and treatment of a patient with hypertension and chills induced by uracillin were analyzed retrospectively,and the correlation of adverse drug reactions(ADR)was analyzed The Chinese and English databases of CNKI,Vip,PubMed and Web of Science were searched to analyze the ADR case reports related to yurekline.Results The patient experienced a sudden increase in blood pressure with chills and sweats during the use of uracillin,and the adverse reaction was relieved gradually after withdrawal.According to Naranjo's ADR assessment scale and our manual of ADR reporting and monitoring,the association between uracillin and increased blood pressure with chills was"Probably".Conclusions The increase of blood pressure is a rare side effect of uracillin,so it is necessary to monitor the patients'blood pressure actively during the course of medication.Once the patients have the symptoms of blood pressure fluctuation,body shivering and mental abnormality,the clinic should judge and stop the medication in time to ensure the safety of the patients'medication.
