Comprehensive Clinical Evaluation of Injectable Anti-inflammatory and Hepatoprotective Drugs for the Treatment of Drug-induced Liver Injury
10.3870/j.issn.1004-0781.2025.10.025
- VernacularTitle:注射用抗炎保肝类药物治疗药物性肝损伤的临床综合评价
- Author:
Jing XIE
1
;
Bin XU
;
Yu CHEN
;
Hongwei YU
;
Xingang LI
;
Pengfei JIN
;
Jing TANG
;
Wei LIU
Author Information
1. 首都医科大学附属北京佑安医院药学部,北京 100069
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory and hepatoprotective drugs;
Drug-induced liver injury;
Comprehensive clinical evaluation
- From:
Herald of Medicine
2025;44(10):1671-1677
- CountryChina
- Language:Chinese
-
Abstract:
Objective To conduct comprehensive clinical evaluation of injectable anti-inflammatory and hepatoprotective drugs with different mechanisms of action,and to provide a basis for drug selection and rational drug use in medical institutions.Methods Twenty-two experts in clinical and pharmacological fields were organized to construct a quantitative rating scale for the comprehensive clinical evaluation of drugs by applying the literature research method,expert interview method,and Delphi method,through seminars and interviews,and by referring to the real-world clinical data and evidence-based medical evidence such as the Guidelines for the Management of Comprehensive Clinical Evaluation of Drugs,so as to conduct a comprehensive evaluation of eight injectable anti-inflammatory and hepatoprotective drugs in terms of six dimensions:effectiveness,safety,economy,appropriateness,accessibility and maturity.Results A comprehensive clinical evaluation index system of injectable anti-inflammatory and hepatoprotective drugs for the treatment of drug-induced liver injury was constructed,including 6 first-level indexes,14 second-level indexes,and 27 third-level indexes,with a total of 100 points.The scoring results showed that among the evaluated varieties,the scores were,in descending order,magnesium isoglycyrrhizinate injection,compound glycyrrhizin injection,polyene phosphatidylcholine injection,reduced glutathione for injection,thiopronin injection,compound ammonium glycyrrhizinate injection,acetylcysteine injection and diammonium glycyrrhizinate injection.Conclusion The constructed quantitative rating scale for comprehensive clinical evaluation of drugs is operable,and the evaluation process can provide academic guidance for exploring the standardized path of comprehensive clinical evaluation of drugs,which needs to be applied in combination with the actual drug varieties of the medical institutions as well as the specific conditions of the patients to make individualized therapeutic choices.
