Association between plasma complement levels and white matter microstructural abnormalities in first-episode schizophrenia
10.3969/j.issn.1002-0152.2025.08.004
- VernacularTitle:首发精神分裂症患者血浆补体与脑白质微结构异常相关性研究
- Author:
Lingqi JIAN
1
;
Shiyi HU
;
Hua YU
;
Peiyan NI
;
Junzhe RAN
;
Wei WEI
;
Liansheng ZHAO
;
Chengcheng ZHANG
;
Tao LI
Author Information
1. 四川大学华西医院心理卫生中心(成都 610041)
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
White matter;
Magnetic resonance imaging;
Diffusion tensor imaging;
Inflammation;
Complement system proteins;
Limbic system
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(8):469-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate alterations in plasma complement levels and white matter imaging characteristics,along with their relationship in patients with first-episode schizophrenia(SCZ).Methods Thirty-eight patients with first-episode schizophrenia and 42 healthy controls were enrolled.Whole-brain diffusion tensor imaging(DTI)was performed using a Philips 3.0 T MRI scanner.Tract-based spatial statistics(TBSS)combined with the Johns Hopkins University(JHU)white matter labels atlas was used to extract and compare white matter characteristics between the two groups.Plasma levels of complement components(C1q,C3,C4,factor B,factor H,and factor P)were measured using the MILLIPLEX? human complement assay kit via multiplex analysis.Spearman correlation analysis was conducted to examine the association between plasma complement levels and white matter features.Results The radial diffusivity(RD)of the left fornix/stria terminalis was significantly higher in the patient group compared to the control group[(0.62±0.04)×10-3mm2/s vs.(0.60±0.03)×10-3mm2/s,PFDR=0.048)].Factor H[677.71(551.58,846.21)ng/mL vs.582.76(513.93,729.71)ng/mL,P=0.041]and factor P[71.36(57.30,95.99)ng/mL vs.60.08(46.67,80.03)ng/mL,P=0.011]were both significantly elevated compared to the control group.Moreover,RD values in the left fornix/stria terminalis were negatively correlated with plasma C3 levels in the patient group(r=-0.362,P=0.025).Conclusion Patients with first-episode schizophrenia exhibit white matter microstructural abnormalities in left fornix/stria terminalis,which are significantly associated with plasma complement levels.
