A comparative study of peripheral nerve conduction function in patients with Alzheimer disease and late-life depression
10.3969/j.issn.1002-0152.2025.08.003
- VernacularTitle:阿尔茨海默病与老年期抑郁障碍患者周围神经传导功能对比研究
- Author:
Xinyi QIAN
1
;
Jun ZHAO
;
Shifu XIAO
;
Ling YUE
Author Information
1. 上海交通大学医学院附属精神卫生中心,上海交通大学阿尔茨海默病诊治中心(上海 200030)
- Publication Type:Journal Article
- Keywords:
Late-life depression;
Alzheimer disease;
Dementia;
Cognitive impairment;
Sensory nerve conduc?tion;
Motor nerve conduction;
Nerve conduction velocity
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(8):462-468
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the peripheral nerve conduction function among elderly individuals with late life depression(LLD),those with Alzheimer disease(AD),and with normal cognition(NC).Methods 29 LLD patients and 30 AD patients hospitalized in the Geriatrics Department,as well as 52 matched NC elderly(60 years old and over)were selected.Test and compare the sensory nerve conduction of the median nerve and the sural nerve,as well as the motor nerve conduction of the median nerve and the common peroneal nerve.The nerve conduction indicators were latency,amplitude,and conduction velocity.Results After controlling for gender,age,height,educational level,and somatic diseases with inter-group differences,the proximal latency[3.13(2.82,3.48)ms vs.3.62(3.10,4.42)ms,P=0.023],amplitude[proximal,(7.20±2.43)mV vs.(4.01±2.99)mV,P<0.001;distal,(6.16±2.25)mV vs.(4.03±3.19)mV,P<0.001],and velocity[(56.23±5.29)m/s vs.(49.44±5.87)m/s,P=0.002]of the median motor nerve conduction in AD group were worse than those in NC group.The latency[proximal,3.13(2.82,3.48)ms vs.4.17(3.36,4.85)ms,P<0.001;distal,7.24(6.82,7.84)ms vs.8.02(7.37,8.83)ms,P<0.001],and amplitude[proximal,(7.20±2.43)mV vs.(3.27±2.80)mV,P<0.001;distal,(6.16±2.25)mV vs.(3.05±2.85)mV,P<0.001]of the median motor nerve conduction in LLD group were worse than those in NC group as well.In terms of the common peroneal motor nerve conduction function,compared to NC group,AD group had slower velocity[(48.77±5.71)m/s vs.(41.86±5.02)m/s,P=0.033],and LLD group had longer proximal latency[4.14(3.38,5.48)ms vs.5.68(5.16,7.55)ms,P<0.001].Conclusion Both AD and LLD showed peripheral motor nerve conduction impairment,but with different patterns of dysfunction.These findings provided new directions for research into the mechanisms of the disease.
