Correlation study between trimethylamine N-oxide and Hashimoto's thyroiditis
10.12092/j.issn.1009-2501.2025.09.007
- VernacularTitle:三甲胺N-氧化物与桥本甲状腺炎的相关性研究
- Author:
Jianxiang JIANG
1
;
Peiyan DU
;
Yurong LIU
;
Haihong LV
Author Information
1. 兰州大学第一临床医学院,兰州 730000,甘肃
- Publication Type:Journal Article
- Keywords:
trimethylamine N-oxide;
intestinal flora;
Hashimoto's thyroiditis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(9):1208-1214
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the correlation be-tween trimethylamine N-oxide(TMAO)and Hashi-moto's thyroiditis(HT)and to provide new ideas for early clinical diagnosis of HT.METHODS:A total of 102 patients with Hashimoto's thyroiditis(HT group)and 204 healthy individuals(control group)were included in the study and clinical data were collected.Serum TMAO levels was determined by stable isotope dilution high-performance liquid chromatography tandem mass spectrometry(HPLC-MS/MS).SPSS 26.0 was used for statistical analysis.RESULTS:Analysis of the baseline data revealed that there was a statistically significant difference between the TMAO levels and gender between the HT group and the control group(P<0.05).In the high-level TMAO group,the proportion of HT(63.7%)was significantly higher than that of the control group(18.6%),the regression analysis showed that high levels of TMAO were correlated with HT and positively correlated with the levels of thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TgAb),Logistic regression analysis further revealed that serum TMAO was a risk factor for the development of HT.CONCLUSION:In the TMAO>6.80 μmol/L group,the level of TMAO was correlat-ed with HT,and the high level of TMAO was posi-tively correlated with TPOAb and TgAb,which were risk factors for the occurrence of HT.It is suggested that TMAO can predict the risk of HT and has cer-tain clinical value.
