Research progress on the mitophagy in oocytes
10.3760/cma.j.cn101441-20221011-00444
- VernacularTitle:卵母细胞线粒体自噬的研究进展
- Author:
Rui WU
1
;
Guanyou HUANG
1
;
Shuyun ZHAO
1
Author Information
1. 贵州医科大学附属医院生殖医学中心，贵阳 550001
- Publication Type:Journal Article
- Keywords:
Oocyte;
Mitophagy;
Oxidative stress
- From:
Chinese Journal of Reproduction and Contraception
2023;43(12):1291-1295
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria are the most abundant organelles in oocytes, and their quantity and quality directly affect the quality and developmental potential of oocytes, thus determining the outcome of female fertility. Mitophagy, as a large autophagy that selectively degrades dysfunctional mitochondria, is crucial for mitochondrial function maintenance and homeostasis in oocytes. In recent years, studies on the functions and mechanisms of mitophagy in oocytes have gradually become a research hotspot in the field of female reproduction. This paper reviews the mitochondrial autophagy in oocyte maturation, oocyte aging, and mitochondria autophagy involving in drugs and environmental stimuli which affects oocyte quality, and its significance in assisted reproductive technology. We expect to benefit for further understanding the biological significance of mitophagy in oocytes, and to inform the improvement of oocyte quality invitro or invivo.
