Association of the triglyceride glucose-body mass index with the extent of coronary artery disease in patients with premature coronary artery disease
10.20039/j.cnki.1007-3949.2025.10.006
- VernacularTitle:甘油三酯葡萄糖体质指数与早发冠心病患者冠状动脉病变程度的相关性
- Author:
Yanqi WANG
1
;
Yi ZHENG
1
Author Information
1. 徐州市中心医院心内科,江苏省徐州市 221000
- Publication Type:Journal Article
- Keywords:
triglyceride glucose-body mass index;
premature coronary artery disease;
severity of coronary artery disease
- From:
Chinese Journal of Arteriosclerosis
2025;33(10):870-876
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the relationship between the triglyceride glucose-body mass index(TyG-BMI)and the extent of coronary artery disease in patients with premature coronary artery disease(PCAD).Methods A ret-rospective analysis was performed on the clinical data of 533 PCAD patients diagnosed by coronary angiography at Xuzhou Central Hospital from January 2023 to December 2023.Patients were divided into three groups based on TyG-BMI ter-tiles:group T1(TyG-BMI ≤228.27),group T2(228.27＜TyG-BMI ≤248.90),and group T3(TyG-BMI＞248.90).The extent of coronary artery disease was quantitatively assessed using the Gensini score,which was categorized into low/mid-risk(Gensini score≤70)and high-risk(Gensini score＞70)groups.Univariate and multivariate Logistic regression models were used to analyze the relationship between TyG-BMI and the occurrence of high Gensini score coronary artery dis-ease.Spearman correlation analysis was employed to assess the correlation between TyG-BMI and Gensini score.ROC curve was used to analyze the predictive value of TyG-BMI for severe coronary artery disease.Results Patients in group T3 had more multi-vessel lesions and higher Gensini scores(P＜0.001).Logistic regression analysis showed that a high level of the TyG-BMI was an independent risk factor for severe coronary artery disease in patients with PCAD(OR=1.031,95％CI:1.021～1.040,P＜0.001).Compared with group T1,the risk for severe coronary artery disease in group T3 was 3.57-fold higher(OR=3.57,95％CI:2.170～5.870,P＜0.001).Spearman correlation analysis showed that TyG-BMI was positively correlated with the severity of coronary artery disease(r=0.202,P＜0.001).ROC curve a-nalysis showed that the area under curve of TyG-BMI was 0.704(95％CI:0.656～0.752),which was superior to that of the TyG index in predictive value(P＜0.05).Conclusion A high level of the TyG-BMI can be used as an effective predictor of severe coronary artery disease in patients with PCAD.
