Expression of HBV RNA in hepatitis B virus-associated hepatocellular carcinoma
10.3969/j.issn.1006-5725.2025.21.020
- VernacularTitle:HBV RNA预测乙型肝炎病毒相关肝细胞癌发病的价值
- Author:
Ya CHEN
1
;
Xiaoy-ong LUO
1
;
Yinghua CHEN
1
;
Yawen LUO
1
Author Information
1. 遵义医科大学附属医院感染科(贵州遵义 563000)
- Publication Type:Journal Article
- Keywords:
HBV RNA;
chronic hepatitis B;
hepatitis B virus associated hepatocellular carcinoma
- From:
The Journal of Practical Medicine
2025;41(21):3435-3441
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of HBV RNA in hepatitis B virus-associated hepatocel-lular carcinoma(HBV-HCC).Methods A total of 259 patients with chronic hepatitis B(CHB)and 41 HBV-HCC patients treated in the outpatient or inpatient department of the Affiliated Hospital of Zunyi Medical University from December 2023 to January 2025 were enrolled as subjects.The differences in age,sex,and levels of HBV RNA,HBV DNA,ALT,AST,and TBIL between the two groups were compared.Differences in viral load between HBV RNA and HBV DNA within each group were compared.Correlations between HBV RNA and HBV DNA,ALT,AST,and TBIL within each group were analyzed.Diagnostic efficacy of HBV RNA for HBV-HCC was determined using receiver operating characteristic(ROC)curve analysis.Results The HBV-HCC group had significantly higher HBV RNA load,HBV RNA positivity rate,ALT,AST and TBIL levels and proportion of male patients and older age compared to the CHB group(P<0.05).Scatter plot analysis revealed a higher HBV DNA load compared to the HBV RNA load in the CHB group(P<0.000 1).Correlation analysis showed that HBV RNA was positively correlated with HBV DNA in both groups(P<0.05).In the CHB group,HBV RNA was positively correlated with ALT,AST and TBIL(P<0.001).The ROC curve showed that the area under the curve(AUC)for HBV RNA was 0.6923(P<0.000 1),with an optimal cut-off value of≥2.5 log10 copies/mL for diagnosing HBV-HCC.Conclusion Serum HBV RNA levels demonstrate high sensitivity and specificity for identifying HBV-HCC and can serve as a reliable indicator for predicting the occurrence of HBV-HCC.
