Research progress of exosomes in oocyte development and related diseases
10.3760/cma.j.cn101441-20220528-00235
- VernacularTitle:外泌体在卵母细胞发育及相关疾病中的研究进展
- Author:
Li YU
1
;
Qingqing SHEN
;
Te LIU
;
Wei GUO
Author Information
1. 复旦大学附属中山医院检验科，上海 200032
- Publication Type:Journal Article
- Keywords:
Exosomes;
MicroRNAs;
Long-noncoding RNA;
Circular RNA;
Follicle development
- From:
Chinese Journal of Reproduction and Contraception
2023;43(9):982-987
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are vesicles derived from the cell membrane system that originate from endosomal multivesicular bodies and are released into the tissue fluid. Exosomes serve as carriers for intercellular communication and contain proteins, lipids, coding or non-coding RNAs derived from their donor cytoplasm. The follicle is an important microenvironment for oocyte development. In the process of oocyte development, substances are transferred between the oocyte and the cumulus and granulosa cells around the follicle through the extracellular follicle, thereby regulating the gene expression in oocytes. Under normal and pathological conditions, exosomes are released by a variety of cells and participate in the occurrence and development of various diseases, and can be used as candidate biomarkers for diseases and potential targets for therapeutic intervention. The aim of this review is to present the mechanism of microRNA, long non-coding RNA and circular RNA in exosomes in the developmental state of oocytes and their role in ovarian and uterine related reproductive system diseases such as polycystic ovary syndrome, ovarian cancer and endometriosis. The detection of exosomes can provide an in-depth understanding of the developmental status of oocytes, which is helpful for the prevention, diagnosis and treatment of diseases.
