Research on Keap1-Nrf2/ARE system resisting defective decidualization
10.3760/cma.j.cn101441-20220928-00419
- VernacularTitle:Keap1-Nrf2/ARE系统抵抗蜕膜化缺陷的研究进展
- Author:
Jing ZHANG
1
;
Ruihong MA
1
;
Jing LIU
1
;
Tian XIA
1
Author Information
1. 天津中医药大学第一附属医院生殖医学科 国家中医针灸临床医学研究中心，天津 300300
- Publication Type:Journal Article
- Keywords:
Pregnancy outcome;
Nrf2;
Decidualization;
Cellular defense
- From:
Chinese Journal of Reproduction and Contraception
2023;43(11):1198-1202
- CountryChina
- Language:Chinese
-
Abstract:
Defective decidualization can lead to infertility and other poor pregnancy outcomes. A variety of adverse stressors such as oxidative stress, inflammation, and toxic exposure are all triggers of defective decidualization. In recent years, the Keap1-Nrf2/ARE system, as a key regulator of cellular defense mechanisms, has become a hot topic of research in various chronic diseases. In addition to its classical cellular defense role, Nrf2 has been confirmed to be activated by estrogen and progesterone, and may regulate decidualization through the FoxO1 pathway, thus making it an important target for clinical improvement of adverse pregnancy outcomes. This article provides an overview of the evidence supporting the involvement of the Keap1-Nrf2/ARE system in regulating the decidualization process through mechanisms such as combating stress-induced damage, interacting with female pregnancy hormones, and regulating the FoxO1 factor.
