Role of Sirtuin Protein Family in Cancer:A Potential Novel Therapeutic Target
10.3870/j.issn.1004-0781.2025.10.022
- VernacularTitle:Sirtuins蛋白家族在肿瘤中的作用:一种潜在的药物治疗新靶点
- Author:
Yushi ZHAO
1
;
Baichuan WANG
;
Yong HAN
;
Ting WANG
Author Information
1. 武汉科技大学医学院,武汉 430065;武汉科技大学职业危害识别与控制湖北省重点实验室,武汉 430065;华中科技大学同济医学院附属协和医院药学部,武汉 430022
- Publication Type:Journal Article
- Keywords:
Sirtuin protein family;
Oncogene;
Tumor suppressor gene;
Therapeutic target
- From:
Herald of Medicine
2025;44(10):1655-1660
- CountryChina
- Language:Chinese
-
Abstract:
The sirtuin protein family represents a highly conserved group of NAD+-dependent protein deacetylases,comprising seven isoforms in mammals,each with distinct subcellular localizations and biological functions.They play important roles in regulating metabolic reprogramming,cell death,and the development of tumor phenotypes.Consequently,modulating deacetylase activity is regarded as a promising therapeutic option in pathology.This article focuses on elucidating the roles and molecular mechanisms of sirtuins in tumor evolution,as well as the application of sirtuin activators and inhibitors in oncology,to guide targeted therapy and drug development for related malignancies.
