Analysis of clinical outcomes of sequential embryo transfer in patients with recurrent implantation failure
10.3760/cma.j.cn101441-20220610-00255
- VernacularTitle:序贯胚胎移植法应用于反复种植失败者的临床结局分析
- Author:
Yongmei ZHANG
1
;
Liu LIU
1
;
Songying ZHANG
1
Author Information
1. 浙江大学医学院附属邵逸夫医院生殖医学中心 浙江省生殖障碍诊治研究重点实验室，杭州 310000
- Publication Type:Journal Article
- Keywords:
Recurrent implantation failure;
Sequential embryo transfer;
Blastocyst;
Pregnancy rate
- From:
Chinese Journal of Reproduction and Contraception
2023;43(9):913-918
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of sequential embryo transfer on improving clinical pregnancy outcomes during the frozen-thawed embryo transfer cycle in patients with recurrent implantation failure (RIF).Methods:A retrospective cohort study was performed in patients who underwent frozen-thawed embryo transfer from January 2019 to September 2021 in the Center of Reproductive Medicine, Sir Run Run Shaw Hospital, Zhejiang University, including 842 patients with RIF. According to the embryo transfer plan, the patients were divided into four groups, including the cleavage embryo transfer group ( n=316), two blastocysts transfer group ( n=212), sequential embryo transfer group ( n=236) and single blastocyst transfer group ( n=78). The pregnancy outcome was compared among the four groups. Results:The clinical pregnancy rate of cleavage embryo transfer group [39.6% (125/316)] was significantly lower than that of two blastocysts group [61.8% (131/212), P<0.001] and sequential embryo transfer group [53.0% (125/236), P<0.001], and there was no significant difference between two blastocysts group and sequential embryo transfer group ( P>0.05). The clinical pregnancy rate was similar in cleavage embryo transfer group and single blastocyst transfer group [37.2% (29/78)]. The implantation rate of cleavage embryo transfer group [23.9% (151/632)] was significantly lower than that of two blastocysts transfer group [43.4% (184/424)], sequential embryo transfer group [33.7% (159/472)] and single blastocyst transfer group [35.9% (28/78)], and there were significant differences among the four groups (all P<0.001). The multiple births rate in two blastocysts transfer group [39.7% (52/131)] was significantly higher than that in cleavage embryo transfer group [23.2% (29/125), P<0.001], sequential embryo transfer group [26.4% (33/125), P<0.001] and single blastocyst transfer group [0% (0/33), P<0.001], and there was a significant difference between cleavage embryo transfer group and two blastocysts transfer group ( P<0.001). Conclusion:For patients with RIF, sequential embryo transfer can improve the clinical pregnancy rate compared with cleavage embryo transfer and single blastocyst transfer, and reduce the multiple pregnancy rate compared with double blastocysts transfer.
