A case study on multidisciplinary support in comprehensive diagnosis and treatment of combined small cell lung cancer and exploration of MRD
- VernacularTitle:复合型小细胞肺癌多学科诊疗及MRD探索1例
- Author:
Chang LIU
1
;
Fanlu MENG
;
Jing YANG
;
Rongxin ZHANG
;
Junping WANG
;
Jianhua XIONG
;
Diansheng ZHONG
Author Information
- Publication Type:Journal Article
- Keywords: neoplasms by histologic type; chemoradiotherapy; neoplasm,residual; combined small cell lung cancer; brain metastasis; multi-disciplinary treatment
- From: Tianjin Medical Journal 2025;53(10):1091-1097
- CountryChina
- Language:Chinese
- Abstract: Combined small cell lung cancer(C-SCLC)accounts for approximately 20%of all SCLC cases,while the propotion of C-SCLC mixed with squamous cell carcinoma component comprises less than 3%.At the pathological level,accurate diagnosis requires to distinguish it from other lung tumor types,and even rely on molecular testing.This article presents a case of a 67-year-old patient initially diagnosed with a peripheral lung tumor.The patient underwent comprehensive multidisciplinary management,including surgical resection,postoperative pathological differential diagnosis,chemotherapy,thoracic radiotherapy,brain metastasis,cranial radiotherapy,dynamic follow-up of imaging changes after cranial radiotherapy,and cranial surgery.Molecular residual disease(MRD)monitoring was integrated at critical time points during dynamic monitoring to inform personalized treatment decisions.The early MDT has brought the patient′s condition under control,and the overall survival of the patient exceeded 30 months.Through the introduction of the diagnosis and treatment process of this patient,we aim to offer novel perspectives on clinical decision-making for C-SCLC.
