The relationship between HMOX1 and MAPK14 with the onset and prognosis of sepsis-induced acute lung injury in children
10.11958/20251919
- VernacularTitle:HMOX1和MAPK14与脓毒症急性肺损伤患儿发病和预后的关系
- Author:
Bo LI
1
;
Hong LIN
;
Lanying HUANG
;
Lingyu LI
Author Information
1. 江油市人民医院儿科(邮编 621700)
- Publication Type:Journal Article
- Keywords:
sepsis;
acute lung injury;
ferroptosis;
heme oxygenase-1;
mitogen-activated protein kinase 14;
prognosis;
child
- From:
Tianjin Medical Journal
2025;53(10):1052-1056
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the ferroptosis-related molecules heme oxygenase-1(HMOX1)and mitogen-activated protein kinase 14(MAPK14)with the onset and prognosis of acute lung injury(ALI)in children with sepsis.Methods A total of 102 children with sepsis were selected,including 54 in the ALI group and 48 in the non-ALI group.Clinical data,laboratory tests,organ function scores and serum levels of HMOX1 and MAPK14 were compared between the two groups.The mortality rates of children with different levels of HMOX1 and MAPK14 at 28-day and 90-day were analyzed.Results Compared with the non-ALI group,procalcitonin(PCT),lactate(Lac),pediatric organ dysfunction Logistic-2 score(PELOD-2),pediatric risk of mortality score version 3(PRISM III)and sequential organ failure assessment(SOFA)scores were increased in the ALI group(P＜0.05).Serum levels of HMOX1 and MAPK14 were significantly higher in the ALI group than those in the non-ALI group(P＜0.05).HMOX1 and MAPK14 showed good predictive value for the occurrence of ALI in sepsis patients,with AUC values of 0.872(95%CI:0.791-0.930)and 0.825(95%CI:0.737-0.893),and the optimal cutoff values were 3.1 μg/L and 3.8 μg/L,respectively.After grouping by the cutoff values of HMOX1 and MAPK14,there were no significant differences in the 28-day and 90-day mortality rates in children with different levels of HMOX1 and MAPK14(P＞0.05).Conclusion The expression levels of serum HMOX1 and MAPK14 increase in the early stage of sepsis-related ALI,which may serve as biomarkers for the onset of ALI,and they have no significant impact on the prognosis of children.
