Molecular mechanisms and synergistic strategies of combination therapy in breast cancer
10.13431/j.cnki.immunol.j.20250094
- VernacularTitle:乳腺癌联合治疗分子机制及协同策略
- Author:
Jiahao SI
1
;
Jinglu SHI
;
Zheng WEI
;
Jin GE
;
Jiajia WU
;
Min YANG
;
Zichu LI
;
Weiwei LIN
;
Yan ZHANG
;
Xueqin WANG
;
Na LI
;
Shaobo DUAN
Author Information
1. 郑州大学人民医院超声科,郑州 450003
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
combination therapy;
signaling pathways;
biomarkers;
review
- From:
Immunological Journal
2025;41(9):667-678
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is the leading cause of cancer-related mortality among women worldwide and has drawn extensive research attention.Owing to its molecular heterogeneity,drug resistance,and low therapeutic response,single-modality treatments often fail to achieve satisfactory efficacy or broad applicability.Combination therapy,designed based on the pathophysiological characteristics,related signaling pathways,and biomarkers of breast cancer,has emerged as a promising approach for improving therapeutic outcomes.With the advancement of research on combination strategies,the understanding of their molecular mechanisms—particularly key signaling pathways and biomarkers—has become increasingly important.However,comprehensive reviews addressing these molecular mechanisms and synergistic strategies remain scarce.This article summarizes recent advances in combination therapy for breast cancer,providing a comprehensive review of recent combination therapies for breast cancer and their underlying molecular mechanisms,and focusing on key signaling pathways involved in combination therapy and synergistic strategies,thereby providing theoretical insights and reference for researchers,graduate students,and clinicians engaged in the development of novel combination therapeutic strategies for breast cancer and related malignancies.
