Study on the correlation between left ventricular myocardial fibrosis and right ventricular function injury in coronary heart disease via cardiac MR

Luying NI; Qian ZHANG; Changjin BAO; Mengmeng YU; Di ZHANG; Xingyue JIANG

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Study on the correlation between left ventricular myocardial fibrosis and right ventricular function injury in coronary heart disease via cardiac MR

VernacularTitle:心脏MR评价冠心病左心室心肌纤维化与右心室功能损伤的相关性研究
Author: Luying NI ¹ ; Qian ZHANG ¹ ; Changjin BAO ¹ ; Mengmeng YU ¹ ; Di ZHANG ¹ ; Xingyue JIANG ¹
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1. 滨州医学院附属医院放射科,山东滨州 256603
Publication Type:Journal Article
Keywords: coronary heart disease; cardiac function; magnetic resonance imaging; T1 mapping
From: Journal of Practical Radiology 2025;41(10):1658-1662
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between left ventricular myocardial fibrosis and right ventricular function injury in coronary heart disease(CHD)using cardiac magnetic resonance(CMR).Methods A total of 40 CHD patients and 32 healthy volunteers were selected.Based on the late gadolinium enhancement(LGE)images,CHD patients were divided into LGE(+)and LGE(-)groups.Biventricular function parameters,T1 value of the left ventricular myocardium and left ventricular LGE extent(％LGE)were measured and compared between the two groups.Pearson or Spearman correlation analysis was used to analyze the relationship among CMR parameters.Multivariate logistic regression was used to analyze the related factors of right ventricular dysfunction.Results Compared with the LGE(-)group,the right ventricular ejection fraction(RVEF),right ventricular stroke volume index(RVSVI)and right ventricular fractional area change(RVFAC)were decreased in the LGE(+)group(P<0.05).RVEF,RVSVI and RVFAC were negatively correlated with％LGE and native T1 value of the left ventricular myocardium,and native T1 value of the left ventricular myocardium was independently correlated with right ventricular dysfunction(P<0.05).Conclusion CMR reveals the relationship between left ventricular myocardial fibrosis and right ventricular function injury in CHD patients,which is helpful for the early clinical detection and treatment of right ventricular injury.