Impact of female body mass index on clinical outcomes in patients treated with intrauterine insemination: a single-center cohort study
10.3760/cma.j.cn101441-20230201-00037
- VernacularTitle:女性体质量指数对宫腔内人工授精妊娠结局的影响：一项单中心大样本队列研究
- Author:
Zhaofeng PENG
1
;
Zhiqin BU
1
;
Fang WANG
1
;
Yile ZHANG
1
Author Information
1. 郑州大学第一附属医院生殖医学中心，郑州 450052
- Publication Type:Journal Article
- Keywords:
Body mass index;
Pregnancy outcome;
Intrauterine insemination;
Artificial insemination by husband;
Artificial insemination by donor
- From:
Chinese Journal of Reproduction and Contraception
2023;43(12):1209-1215
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the impact of female body mass index (BMI) on clinical outcomes in patients treated with intrauterine insemination (IUI).Methods:This study was a retrospective cohort study. A total of 21 137 patients who visited the Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University from January 2010 to December 2021 were recruited. The patients underwent the first IUI cycles, including artificial insemination by husband (AIH) and artificial insemination by donor (AID). According to clinical pregnancy or not, it is divided into pregnancy group and non-pregnancy group. The basic parameters between clinical pregnancy group and non-clinical pregnancy group were compared. According to the BMI, patients were divided into 4 groups, group A: BMI≤18.5 kg/m 2, group B: 18.6-23.9 kg/m 2, group C: 24.0-27.9 kg/m 2and group D: BMI≥28.0 kg/m 2. Patients' basic parameters and clinical outcomes were compared among the four groups. Multivariate logistic regression analysis was used to explore the impact of BMI on pregnancy outcomes. Results:In all IUI cycles, BMI was significantly different between pregnant patients and non-pregnant patients [(24.58±3.52) kg/m 2vs. (23.35±4.20) kg/m 2, P<0.001]. In AIH cycles, clinical pregnancy rate [18.21% (877/4 815), 17.12% (222/1 297)] and early spontaneous miscarriage rate [17.10% (150/877), 21.62% (48/222)] were significantly higher in patients of group C and group D than in group A [11.24% (130/1 157), 10.77% (14/130)] and group B [13.40% (1 229/9 174), 15.30% (188/1 229)]. The differences among the 4 groups were statistically significant ( P=0.012, P=0.003). However, BMI was not associated with clinical pregnancy rate in multivariate logistic analysis, but obesity was a predictor for early spontaneous miscarriage ( OR=1.63, 95% CI: 1.25-1.95, P=0.003). In AID cycles, pregnancy outcomes were comparable among the four BMI groups. Obesity significantly increased early spontaneous miscarriage rate ( OR=1.58, 95% CI: 1.14-1.87, P=0.016). Conclusion:Female BMI is not associated with clinical outcomes in IUI cycles. Obesity is a predictor for early spontaneous miscarriage in both AIH and AID cycles.
