Epidemiological analysis of high-risk HPV infection and genotype distribution in 13 105 women in Zhongguancun area,Beijing
- VernacularTitle:北京市中关村地区13 105例女性高危型HPV感染及基因分型流行病学分析
- Author:
Yanyan YANG
1
;
Ping WANG
1
;
Xue YI
1
;
Jinzhu PENG
1
;
Yu HE
1
;
Wenyu ZHANG
1
;
Lei CHEN
1
;
AZIYA
1
Author Information
- Publication Type:Journal Article
- Keywords: papillomaviridae; uterine cervical neoplasms; epidemiology; papillomavirus vaccines; genotype; human papillomavirus; Zhongguancun; multiple infections
- From: Tianjin Medical Journal 2025;53(10):1086-1090
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the epidemiological characteristics of human papillomavirus(HPV)infection in women in the Zhongguancun area of Beijing,and to evaluate the infection rates and genotype distribution between different populations and age groups.Methods A retrospective analysis was conducted on HPV genotyping results of 13,105 women who visited the gynecology outpatient department or underwent routine health check-ups at Zhongguancun Hospital from March 2019 to April 2024.High-risk HPV genotypes(15 types)were detected using a fluorescence PCR assay.Positive cases were classified as single,dual or multiple(≥3)infections based on the number of genotypes.Subjects were stratified into six age groups(≤30,31-40,41-50,51-60,61-70,and≥71 years),and the characteristics of infection by type and age group were analyzed.Results The overall HPV positivity rate was 10.78%(1,413/13,105),with a significantly higher rate in the outpatient group than that in the health check-up group(16.36%vs.6.06%,P<0.01).The three most prevalent genotypes were HPV52(18.83%),HPV58(13.85%),and HPV16(11.28%).Single infections accounted for 79.19%of cases,dual infections for 15.93%and multiple infections for 4.88%.Age distribution showed a U-shaped pattern,with higher infection rate in women aged≤30 years(15.06%)and 61-70 years(13.19%),and the lowest rate in the≥71 years(8.09%).Notably,women aged≤30 years had the highest proportion of multiple infections(31.72%).Conclusion These findings provide a basis for cervical cancer screening strategies,HPV vaccination promotion and individualized prevention of cervical cancer in this region.
