Ultrasound Characteristics of Breast Cancer with Different Gene Expression:A Comparative Study
10.3969/j.issn.1005-5185.2025.10.007
- VernacularTitle:不同分子生物学特征乳腺癌的超声征象比较
- Author:
Meiling HUANG
1
;
Lin SANG
;
Jingjing XIAO
;
Changjiao YAN
;
Ting WANG
Author Information
1. 空军军医大学西京医院甲乳血管外科,陕西 西安 710032
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Ultrasonography;
Molecular typing;
Immunohistochemistry;
Pathology,surgical
- From:
Chinese Journal of Medical Imaging
2025;33(10):1063-1071
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the ultrasound characteristics of female breast cancer patients with different molecular types,and improve the diagnostic value of ultrasound.Materials and Methods The ultrasound diagnostic data of breast cancer patients in Xijing Hospital,the Air Force Medical University from January 2021 to July 2023 were retrospectively analyzed,and the ultrasound diagnosis of breast cancer patients from the aspects of molecular typing and related human epidermal growth factor receptor-2(HER-2)expression and Ki-67 expression were analyzed.Results A total of 1 405 patients were included in this study,including 240 patients with Luminal A type,631 patients with Luminal B type,162 patients with HER-2+hormone receptor(HR)-type,207 patients with HER-2+HR+type and 165 patients with triple-negative breast cancer.Among the ultrasound characteristics of female breast cancer with different molecular classifications,there were statistical differences in breast imaging reporting and data system classification,edge angulation,spiculation,posterior echo and calcification(χ2=13.652-143.178,all P<0.05).According to the analysis of different degrees of invasion,there were statistical differences in breast imaging reporting and data system classification,edge angulation,spiculation,posterior echo and calcification from the Lumina group(Luminal A,Luminal B)and the aggressive group(HER-2+HR-,HER-2+HR+and triple-negative)(χ2=4.702-17.587,all P<0.05).The HER-2-negative and HER-2-positive groups of patients had significant differences in shape,edge angulation,spiculation and calcification,with statistical differences(χ2=3.947-7.944,all P<0.05).According to the Ki-67 level analysis,it was found that edge angulation,spiculation and posterior echo were influencing factors,with statistical differences(χ2=9.309-56.380,all P<0.05).Conclusion Breast cancer with different molecular expression has its own ultrasound characteristics.Preoperative ultrasound can provide a certain reference basis for the diagnosis,treatment and prognosis assessment of breast cancer.
