Causal diagrams and criteria for identifying and selecting confounders in observational studies
10.12173/j.issn.1005-0698.202503160
- VernacularTitle:观察性研究中的因果图和混杂因素的识别和选择准则
- Author:
Huizhen LIU
1
;
Xiaoqin ZHOU
;
Ting WANG
;
Deying KANG
Author Information
1. 四川大学华西医院临床研究管理部临床研究方案设计与统计办公室(成都 610041)
- Publication Type:Journal Article
- Keywords:
Confounders;
Confounding;
Directed acyclic graphs;
Pre-exposure criterion;
Common cause criterion;
Modified disjunctive cause criterion
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(10):1206-1212
- CountryChina
- Language:Chinese
-
Abstract:
In observational research,a primary objective is to accurately and reliably assess the causal impact of exposure on outcomes.Identifying and properly adjusting for confounding factors is a key prerequisite and central challenge to achieving this goal.Ineffective management of confounders,whether by neglecting significant ones,(leading to residual confounding),or by over-adjusting for irrelevant factors,(introducing collider bias),can distort effect estimates and lead to erroneous scientific conclusions and clinical decisions.Therefore,it is essential to develop and implement systematic,transparent,and reproducible methods for identifying and selecting confounding factors to enhance the validity and reliability of causal inferences in observational studies.This paper provides a systematic review of directed acyclic graphs(DAGs),a robust visual causal modeling tool,and offers a detailed examination of three prominent criteria for selecting confounding factors based on DAGs:the Pre-exposure criterion,the Common cause criterion,and the Modified disjunctive cause criterion.The aim is to equip researchers with a structured and theoretically grounded framework for identifying and selecting confounding factors,thereby improving the process of estimating causal effects in observational studies.
