Effects of vitrification on epigenetic modification and transcriptome of oocytes
10.3760/cma.j.cn101441-20220421-00175
- VernacularTitle:玻璃化冷冻保存对卵母细胞表观遗传修饰及转录组的影响
- Author:
Ju ZHANG
1
;
Yubing LIU
;
Ri-cheng CHIAN
Author Information
1. 苏州大学医学院第一临床学院，苏州 215006
- Publication Type:Journal Article
- Keywords:
Oocyte;
Vitrification;
Epigenetics;
Transcriptome
- From:
Chinese Journal of Reproduction and Contraception
2023;43(8):860-865
- CountryChina
- Language:Chinese
-
Abstract:
Oocyte vitrification has developed as a first-line solution for female fertility preservation, which is widely used in assisted reproductive technology. As the basis of embryonic development, oocytes play an important role in early embryonic development, including epigenetic reprogramming and maternal-to-zygotic transition (MZT). They deserve the key to individual development. Oocyte epigenetic modification and transcriptome are very sensitive to stress induced by vitrification. Vitrification cryopreservation may have adverse effects on the epigenetic modification and transcriptome of oocytes as a strong external stimulus. Through the paper, we mainly reviewed the effects of vitrification on epigenetic modification and transcriptome of oocytes, hoping to provide a theoretical basis for the optimization and improvement of vitrification technology.
