The value of double low-dose iterative reconstruction CT features combined with serum lung cancer autoantibodies in the diagnosis of stage ⅠA lung cancer
10.3969/j.issn.1002-1671.2025.10.010
- VernacularTitle:双低剂量迭代重建CT联合血清肺癌自身抗体对ⅠA期肺癌的诊断价值
- Author:
Xuewen ZHAO
1
;
Xuejun LI
;
Yufei ZHAO
;
Lina ZHANG
;
Jianhong ZHAO
Author Information
1. 兰州大学第二医院放射科,甘肃 兰州 730000;兰州大学第二医院健康管理中心,甘肃 兰州 730000
- Publication Type:Journal Article
- Keywords:
iterative reconstruction;
autoantibody;
stage ⅠA lung cancer
- From:
Journal of Practical Radiology
2025;41(10):1639-1642,1673
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of double low-dose iterative reconstruction CT features combined with serum lung cancer autoantibodies in the diagnosis of stage ⅠA lung cancer.Methods The data of 168 patients with suspected stage ⅠA lung cancer were retrospectively analyzed,and all of them underwent double low-dose iterative reconstruction CT and serum lung cancer autoantibodies examination before treatment.Based on the pathological results as the gold standard,the patients were divided into stage ⅠA lung cancer(119 cases)and benign lesion(49 cases),the diagnostic value of double low-dose iterative reconstruction CT features,serum lung cancer autoantibodies alone and combined both methods in stage ⅠA lung cancer was analyzed.Results Compared with the non-iterative reconstruction CT,the iterative reconstruction CT had significantly lower noise values and significantly higher signal-to-noise ratio and image quality scores(P<0.05).The maximum enhanced CT value and the maximum difference between pre-and post-enhanced CT in stage ⅠA lung cancer were lower than those in benign lesion(P<0.05).The levels of tumor protein 53(p53),stem cell transcription factor 2(SOX2),tumor testicular antigen 7(GAGE7),tumor antigen 4-5(GBU4-5),melanoma antigen A1(MAGE A1),and human carcinoma antigen(CAGE)were higher in stage ⅠA lung cancer than those in benign lesion(P<0.05).The receiver operating characteristic(ROC)curve analysis showed that the area under the curve(AUC)of double low-dose iterative reconstruction CT,serum lung cancer autoantibodies,and the combination of both in the diagnosis of stage ⅠA lung cancer were 0.818[95%confidence interval(CI)0.744-0.893],0.744(95%CI 0.655-0.832),and 0.876(95%CI 0.807-0.945),respectively.Conclusion Double low-dose iterative reconstruction CT features combined with serum lung cancer autoantibodies has high sensitivity and specificity in the diagnosis of stage ⅠA lung cancer.
