Comparison of the application effects between hCG trigger and dual trigger in patients with normal ovarian reserve undergoing controlled ovarian hyperstimulation with antagonist protocol
10.3760/cma.j.cn101441-20230302-00080
- VernacularTitle:比较卵巢储备功能正常患者拮抗剂方案超促排卵中hCG扳机与双扳机的应用效果
- Author:
Libing HE
1
;
Furui CHEN
;
Shiqi CHEN
;
Wei LAI
;
Weixin LIU
;
Yan GONG
Author Information
1. 四川省妇幼保健院 成都医学院附属妇女儿童医院生殖医学中心，成都 610045
- Publication Type:Journal Article
- Keywords:
Fertilization in vitro;
Embryo transfer;
Gonadotropin-releasing hormone antagonist protocol;
Human chorionic gonadotropin trigger;
Dual trigger
- From:
Chinese Journal of Reproduction and Contraception
2023;43(10):1046-1050
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of human chorionic gonadotropin (hCG) trigger and dual trigger on the outcome of in vitro fertilization and embryo transfer (IVF-ET) during superovulation with an antagonist regimen in individuals with normal ovarian reserve function. Methods:A retrospective cohort study was carried out. A total of 239 patients with normal ovarian reserve undergoing IVF-ET from January 2019 to November 2022 at the Reproductive Medicine Center of Sichuan Provincial Women's and Children's Hospital were enrolled. The patients were divided into two groups based on the types of the trigger, group A ( n=143) was given 250 μg recombinant hCG (rhCG), group B ( n=96) was given a dual trigger comprising 0.2 mg gonadotropin releasing-hormone agonist and 2 000 U hCG. The quality of oocytes and embryos, outcomes of pregnancy between the two groups were compared. Results:There were no statistically significant differences in mature oocyte rate, normal fertilization rate, embryo formation rate on day 3 (D3), high-quality embryo rate, blastocyst formation rate, or high-quality blastocyst rate between the two groups (all P>0.05). The incidence of moderate ovarian hyperstimulation syndrome (OHSS) in group A was 1.40% (2/143), which was higher than that of group B [0 (0/96)], but the difference was not statistically significant ( P>0.05). There were no statistically significant differences in embryo implantation rate and clinical pregnancy rate between the two groups during the fresh and frozen-thawed embryo transfer cycles (all P>0.05). Conclusion:In patients with normal ovarian reserve function, there are no significant differences in oocyte and embryo quality, and pregnancy outcome between the dual trigger and hCG trigger. The dual trigger has a tendency to reduce the incidence of OHSS.
