Analyzing the effects of the combination of ginseng-lingbaijusan plus reduction and acupuncture on patients with ulcerative colitis by the theory of"lung-intestinal axis"
10.3969/j.issn.1006-5725.2025.21.023
- VernacularTitle:以"肺-肠轴"理论分析参苓白术散加减与针刺联合对溃疡性结肠炎患者的影响
- Author:
Xin ZHOU
1
;
Bin YUE
;
Yuedong LIU
Author Information
1. 辽宁中医药大学第三临床学院(辽宁 沈阳 110847)
- Publication Type:Journal Article
- Keywords:
ginseng ling baizhu san plus reduction;
based on the theory of"lung-intestinal axis";
acu-puncture;
ulcerative colitis;
intestinal flora balance
- From:
The Journal of Practical Medicine
2025;41(21):3455-3461
- CountryChina
- Language:Chinese
-
Abstract:
Objective Using the theory of the"lung-intestinal axis"to analyze the therapeutic efficacy of acupuncture combined with modified Ginseng-Ling-Bai-Zhu-San in patients with ulcerative colitis and its effects on intestinal flora balance.Methods One hundred and fifty patients with ulcerative colitis who received treatment at our hospital between October 2022 and December 2024 were enrolled in this study.These patients were randomly assigned to either the combination group or the control group,with 75 patients in each group.The control group was treated with modified Shenling Baizhu San,while the combination group received acupuncture in addition to the same herbal formula.After four treatment cycles,changes in TCM symptom scores,intestinal mucosal barrier func-tion,immune microenvironment,gut microbiota balance,and overall clinical efficacy were evaluated and compared between the two groups.Results Compared with the control group,the combination group showed significant improvements after treatment:TCM syndrome scores,IBDQ,DAI,Baron score,DAO,PCT,ET,IL-23,IL-6,IL-1β,CD8+,Enterobacteriaceae,Escherichia coli,Bifidobacterium bifidum,Th17/Treg ratio,and incidence of adverse reactions were significantly reduced;meanwhile,levels of Hb,ALB,PAB,TGF-β1,CD4+,CD4+/CD8+ratio,and Lactobacillus,as well as clinical efficacy,were markedly increased.All differences were statistically significant(P<0.05).Conclusion Effective and safe treatment of ulcerative colitis can be achieved through the combination of acupuncture and a modified formula of Ginseng-Ling-Bai-Juju-San,which may improve intestinal mucosal lesions,reduce inflammation,and stabilize the balance of intestinal flora by modulating the endocrine network of the"lung-intestinal axis".
