Predicting microsatellite instability status in endometrial cancer based on whole-tumor apparent diffusion coefficient histogram
10.3969/j.issn.1002-1671.2025.10.021
- VernacularTitle:基于肿瘤全域表观扩散系数直方图预测子宫内膜癌微卫星不稳定状态
- Author:
Tianhui ZHANG
1
;
Xiumei DU
;
Qiuming WANG
;
Yuhui ZHANG
;
Xi LONG
;
Yingsi YANG
;
Weixiong FAN
Author Information
1. 梅州市人民医院磁共振科,广东 梅州 514031
- Publication Type:Journal Article
- Keywords:
magnetic resonance imaging;
apparent diffusion coefficient;
histogram;
volume of interest;
endometrial cancer;
micro-satellite instability
- From:
Journal of Practical Radiology
2025;41(10):1694-1698
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of predicting microsatellite instability(MSI)status in endometrial cancer based on whole-tumor apparent diffusion coefficient(ADC)histogram.Methods The data of 131 endometrial cancer patients who underwent preoperative MRI examination and were confirmed by pathology were retrospectively analyzed.According to the pathological immu-nohistochemical results,they were divided into microsatellite stability(MSS)group(103 cases)and MSI group(28 cases).The whole-tumor volume of interest(VOI)was outlined using ITK-SNAP software,and ADC histogram analysis was performed using uAI Research Portal software.The t-test or Mann-Whitney U-test were used to compare the differences between the two groups,and multifactorial logistic regression analysis was used to screen independent predictors for the above parameters with differences.The area under the curve(AUC),sensitivity and specificity were calculated using the receiver operating characteristic(ROC)curve.Results The ADC histogram parameters that were statistically significant between groups were ADC10th,ADC90th,ADCmaximum,ADCmedian,ADCmean,ADCrange,ADCinterquartile range,ADCuniformity,ADCvariance,ADCenergy,ADCentropy,ADCtotal energy,ADCroot mean square,ADCmean absolute deviation,ADCrobust mean absolute deviation,all the above parameters were significantly smaller in the MSI group than in the MSS group.Further multifactorial logistic regression analysis results showed that ADCmedian[odds ratio(OR)=1.019,P=0.020]and ADCroot mean square(OR=0.977,P=0.005)were independent predictors of the MSI status in endometrial cancer.The results of ROC curve showed that the AUC of ADCmedian and ADCroot mean square for predicting MSI status were 0.699 and 0.731,respectively,and the AUC of combining the two parameters to predict MSI status was 0.760,with a sensitivity of 57.14%and a specificity of 86.41%.Conclusion The parameters of ADCmedian and ADCroot mean square based on whole-tumor ADC histogram can be used to predict the MSI status of endometrial cancer,and the combined use of these two parameters helps to improve the efficacy of predicting MSI.
