Effect of timing of first frozen-thawed embryo transfer on clinical and perinatal outcomes in whole embryo cryopreservation patients with PPOS protocol: a propensity score matching study
10.3760/cma.j.cn101441-20221018-00457
- VernacularTitle:PPOS方案促排卵全胚冷冻患者首次冻融胚胎移植时机对临床及围产期结局的影响：一项倾向性评分匹配研究
- Author:
Ruxue YANG
1
;
Jiangdi HUANG
1
;
Caihua ZHANG
1
;
Ying XU
1
;
Ya ZHANG
1
;
Danyang LI
1
;
Junwei ZHANG
1
;
Bingnan REN
1
;
Jijun HU
1
;
Yichun GUAN
1
;
Lijun SUN
1
Author Information
1. 郑州大学第三附属医院生殖医学中心，郑州450052
- Publication Type:Journal Article
- Keywords:
Progestin primed ovarian stimulation;
Frozen-thawed embryo transfer;
Time to transfer;
Clinical pregnancy rate;
Perinatal outcome
- From:
Chinese Journal of Reproduction and Contraception
2023;43(11):1158-1162
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the timing of the first frozen-thawed embryo transfer (FET) on clinical and perinatal outcomes in whole embryo freezing patients, who used the medroxyprogesterone acetate (MPA) in progestin primed ovarian stimulation (PPOS).Methods:A retrospective cohort study was conducted to analyze the clinical data of patients with the first FET after ovulation induction by PPOS protocol in Reproductive Medicine Center of the Third Affiliated Hospital of Zhengzhou University from January 2015 to November 2021. According to the time interval between the day of oocytes retrieved and the day of the first FET in the ovulation induction cycle, they were divided into two groups. Group A: transplantation was performed during the first menstrual cycle after oocyte retrieval (time interval ≥24 d and <45 d, n=80), group B: transplantation was performed at least one month apart after oocytes retrieved (time interval ≥45 d, n=1 040). After propensity score matching (PSM), the general data, clinical excretion promotion, embryo laboratory indicators, indicators related to the first FET cycle, clinical and perinatal outcomes were compared between the two groups. Results:Before PSM, the age of group A was significantly higher than that of group B [38 (35, 41) years vs. 37 (32, 40) years, P=0.020]. After PSM, there were no significant differences in general data, ovulation induction cycle data, embryo laboratory indicators, clinical pregnancy rate, live birth rate and perinatal outcomes between the two groups (all P>0.05). Conclusion:Compared with FET at least one month after oocytes retrieval, FET during the first menstrual cycle after PPOS does not affect clinical or perinatal outcomes. FET can be performed as early as possible after oocytes retrieval according to the condition of patients to shorten the time to reach their first live birth.
