Bioinformatics and clinical prognostic analysis of SNX22 gene in thyroid cancer
10.3969/j.issn.1009-9905.2025.10.004
- VernacularTitle:SNX22基因在甲状腺癌中的生物信息学及临床预后分析
- Author:
Wang-jia LI
1
;
Xing-song TIAN
Author Information
1. 山东大学齐鲁医学院(山东 济南 250012);济南市槐荫人民医院 肛肠外科(山东 济南 250117)
- Publication Type:Journal Article
- Keywords:
Thyroid cancer;
SNX22;
Bioinformatics;
Prognosis;
Immune microenvironment
- From:
Chinese Journal of Current Advances in General Surgery
2025;28(10):776-783
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically explore the expression characteristics,molecular functions,and clinical prognostic associations of the SNX22 in thyroid carcinoma(THCA)through bioinformatics analysis and clinical data vali-dation,providing a novel perspective for precision medicine in thyroid cancer.Methods:Gene expression and clinical data of THCA were obtained from the TCGA and GEO databases(GSE3678,GSE65144,GSE82208).R software was used for data preprocessing,differentially expressed gene(DEG)screening,and survival analysis.The expression pat-terns,prognostic value,and immune regulatory roles of SNX22 were evaluated using PPI networks,TIMER/SCNA im-mune correlation analysis,and ESTIMATE scores.Results:Thirteen intersecting DEGs were identified from GEO data-sets,with SNX22 showing significantly higher expression in THCA tumor tissues than in normal tissues(P<0.05).Kaplan-Meier analysis revealed that high SNX22 expression was significantly associated with overall survival(OS)in THCA pa-tients(P=0.001,HR=1.70),with an ROC curve AUC of 0.745.Subgroup analysis indicated significantly elevated SNX22 expression in patients aged≤45 years and with N1 staging(P<0.05).Immune correlation analysis showed that SNX22 expression positively correlated with infiltration of multiple immune cells(P<0.05),while copy number deletions were as-sociated with reduced immune cell infiltration(P<0.05).Conclusion:SNX22 is highly expressed in thyroid cancer and is significantly associated with poor prognosis and immune microenvironment remodeling,thus having the potential to serve as a prognostic marker and immunotherapy target.
