Advances in the development of novel pancreatic duct stent materials:from inert implantation to intelligent degradation through medical-engineering integration
10.7659/j.issn.1005-6947.250466
- VernacularTitle:新型胰管支架材料研发进展:从惰性植入到智能降解的医工融合创新
- Author:
Jingyang YIN
1
;
Zhongchao YI
;
Yanjun WANG
;
Jia SHE
;
Shixiang GUO
Author Information
1. 重庆大学附属人民医院/重庆市人民医院 肝胆胰腺外科,重庆 401147
- Publication Type:Journal Article
- Keywords:
Pancreatic Duct Stents;
Biodegradable Material;
Magnesium Alloy;
Corrosion;
Medicine-Engineering Interdisciplin-ary
- From:
Chinese Journal of General Surgery
2025;34(9):1892-1901
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic duct stents are essential devices for managing chronic pancreatitis,ductal strictures,and postoperative fistula.Conventional plastic and metal stents effectively facilitate pancreatic drainage but often cause infection,restenosis,or migration upon long-term implantation.An ideal stent should provide excellent biocompatibility,efficient drainage,and controllable biodegradation.With advances in material science and medical-engineering integration,stent technology has evolved from inert implantation to intelligent degradation.Biodegradable polymers and metals,particularly magnesium alloys(Mg-Zn-Mn),offer tunable mechanical strength,corrosion resistance,and in vivo degradability.Mg-2Zn-1.0Mn alloy achieves balanced strength and corrosion control through compositional optimization and surface modification.Polymeric stents such as polylactic acid and polydioxanone demonstrate favorable drainage and avoid secondary removal.Composite biodegradable stents,exemplified by the multi-rate ARCHIMEDES model,have received international approval.Supported by 3D printing and smart functionalization-such as drug-eluting or shape-memory designs-next-generation pancreatic stents may achieve integrated functions of support,repair,and tumor inhibition.Future research should emphasize interdisciplinary material design,degradation kinetics under physiological conditions,and long-term biocompatibility to accelerate clinical translation.
