Advances in the diagnosis and treatment of inflammatory bowel disease-associated anemia in children
10.3969/j.issn.1674-8115.2025.09.015
- VernacularTitle:儿童炎症性肠病相关贫血的诊治研究进展
- Author:
Zhiqi WANG
1
;
Ying WANG
Author Information
1. 上海交通大学医学院附属新华医院儿消化营养科,上海 200092
- Publication Type:Journal Article
- Keywords:
inflammatory bowel disease(IBD);
anemia;
child
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2025;45(9):1232-1238
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD)is a group of non-specific chronic gastrointestinal inflammatory disorders of unknown etiology.Patients with IBD often have a variety of extraintestinal symptoms and complications.Anemia is one of the most common extraintestinal manifestations,and its incidence and prevalence in children are higher than in adults.Anemia in children with IBD not only causes non-specific symptoms such as dizziness,headache,and fatigue,but also impacts growth and development,and is closely related to the quality of life.The etiologies of IBD-associated anemia include iron deficiency,anemia of chronic disease,vitamin deficiency,hemolysis,and myelosuppression,among which iron deficiency is the most common.In recent years,in addition to conventional indicators such as hemoglobin,hematocrit,and mean corpuscular hemoglobin,many new indicators for evaluating anemia and iron deficiency have emerged,including soluble transferrin receptor(sTfR),the ratio of sTfR to log ferritin(sTfR-F)index,and reticulocyte hemoglobin content(CHr).In the treatment of IBD-associated anemia in children,oral iron supplementation is the most commonly used therapy in clinical practice,while intravenous iron therapy is not widely used.Although anemia has many negative effects on children with IBD,its diagnosis and treatment are often delayed.This article reviews the pathogenesis,diagnosis,and treatment of IBD-associated anemia in children,in order to improve clinical awareness and attention,and provide a basis for further improving the treatment effect and quality of life.
