Rapid on-site detection of methamphetamine using surface-enhanced raman spectroscopy
10.13618/j.issn.1001-5728.2025.04.013
- VernacularTitle:表面增强拉曼光谱法快速检测甲基苯丙胺
- Author:
Caiyun LIAO
1
;
Yating ZHANG
;
Rongji YANG
;
Liu YANG
;
Guojuan LI
;
Chenxi LIU
;
Wen REN
;
Zhou YANG
Author Information
1. 国家毒品实验室四川分中心,四川成都 610200
- Publication Type:Journal Article
- Keywords:
Surface-enhanced raman spectroscopy(SERS);
Methamphetamine;
Silver nanoparticles;
Rapid detection;
Spiked test
- From:
Chinese Journal of Forensic Medicine
2025;40(4):459-462
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a rapid on-site detection method for methamphetamine(MA)based on surface-enhanced Raman spectroscopy(SERS).Methods Laboratory-synthesized colloidal silver nanoparticles(AgNPs)were employed as SERS substrates to rapidly detect methamphetamine in typical crime scene matrices,including beer,cigarette ash,and plastic containers.Results The method requires no sample pretreatment,is simple to operate,and offers high sensitivity with fast detection speed.The limit of detection(LOD)reached 10 ppb(signal-to-noise ratio,S/N＞3).The qualitative results of methamphetamine analysis from forensic case samples were highly consistent with gas chromatography-mass spectrometry(GC-MS)findings.Conclusion Methamphetamine is frequently encountered in illicit settings and criminal activities.This study achieved rapid detection of methamphetamine in complex matrices(beer,cigarette ash,and plastic containers),demonstrating good application prospects in practice and providing important value for law enforcement,public safety,and criminal investigation.
