Outcomes of IVF/ICSI assisted pregnancy in patients with squamous intraepithelial lession and obstetric outcomes after local treatment
10.3760/cma.j.cn101441-20221213-00561
- VernacularTitle:宫颈鳞状上皮内病变患者行IVF/ICSI助孕结局及宫颈局部手术治疗对围产结局的影响
- Author:
Jing LI
1
;
Hongwu QIAO
1
;
Bingnan REN
1
;
Jiaheng LI
1
;
Mingze DU
1
;
Junwei ZHANG
1
;
Yichun GUAN
1
Author Information
1. 郑州大学第三附属医院生殖中心，郑州 450052
- Publication Type:Journal Article
- Keywords:
Squamous intraepithelial lesions of the cervix;
Fertilization in vitro;
Sperm injections, intracytoplasmic;
Pregnancy outcome;
Local treatment;
Obste
- From:
Chinese Journal of Reproduction and Contraception
2023;43(12):1255-1259
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the impact on the fertility and outcomes of females with squamous intraepithelial lesion (SIL) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and obstetric outcomes after local treatment. Methods:Patients with SIL undergoing IVF/ICSI were set as the SIL group in the Reproductive Center of the Third Affiliated Hospital of Zhengzhou University from January 2016 to December 2020. While, control group was matched using the propensity scoring method in a 1∶3 ratio in accordance with the age, body mass index, and basic follicle-stimulating hormone, antral follicle count and the oocytes retrieval time. Pregnancy outcomes were compared by analyzing the basic conditions of the two groups, the index of the IVF/ICSI cycles, the clinical pregnancy rate and the implantation rate of the fresh cycles, the cumulative pregnancy rate, the cumulative live birth rate, and obstetric outcomes of patients giving live birth after local treatment were also analyzed.Results:The demographic characteristics were of no significant differences between the SIL group and control group (all P>0.05). As for the IVF/ICSI results, no significant differences were observed in the duration of gonadotropins (Gn) used, total dosage of Gn used, No. of oocytes retrieved, normal fertilization rate, No. of available embryos, No. of high-quality embryos, and No. of blastocyst formation between the two groups (all P>0.05). For fresh embryo transfer cycles, the number of transferred embryos was lower, the clinical pregnancy rate and the implantation rate in the SIL group were higher than those in control group, while the differences were not significant (all P>0.05). The differences of time to pregnancy,the cumulative pregnancy rate and the cumulative live birth rate between SIL group and control group were not statistically significant (all P>0.05). There were no statistically significant differences in delivery methods, gestational age, newborn birth weight, and incidence of pregnancy complications between the two groups (all P>0.05). According to local surgical treatment, 79 patients with SIL who achieved live birth were divided into cold knife conization subgroup, loop electrosurgical excisional procedure subgroup, and no-operation subgroup. There were no statistically significant differences in delivery methods, gestational age, newborn birth weight and incidence of pregnancy complications among the three subgroups (all P>0.05). Conclusion:SIL did not affect fertility of patients or assisted pregnancy outcomes of IVF/ICSI, and local surgical treatment does not increase the risk of preterm birth, low birth weight infants.
