Biological functions and regulatory mechanisms of insulin-like growth factor 1 at the maternal-fetal interface
10.3760/cma.j.cn101441-20220707-00288
- VernacularTitle:胰岛素样生长因子1在母-胎界面生物学功能和调节机制进展
- Author:
Linlin WANG
1
;
Yanqiong SHEN
;
Jing YANG
;
Yaya WU
;
Longfei LI
;
Yanxiang CHENG
Author Information
1. 武汉大学人民医院妇产科，武汉 430060
- Publication Type:Journal Article
- Keywords:
Insulin-like growth factor 1;
Metabolism;
Environmental pollutant;
Hormone;
Decidualization
- From:
Chinese Journal of Reproduction and Contraception
2023;43(10):1090-1097
- CountryChina
- Language:Chinese
-
Abstract:
At the maternal-fetal interface, insulin-like growth factor 1 (IGF-1) promotes fetal growth by regulating transport and absorption of amino acid, glucose, and fatty acid in trophoblast cells. Additionally, IGF-1 facilitates proliferation and differentiation of decidual cells, angiogenesis, and decidualization via regulating metabolism, immune responses, and anti- or pro-inflammatory responses of decidual cells. However, more studies are needed to verify the underlying mechanisms of IGF-1 in maternal decidual cells. IGF-1 is regulated by upstream hormones, cytokines, small molecule nutrients, oxygen, and environmental pollutants. Drugs, such as growth hormone, mifepristone, prednisolone and melatonin, can regulate the expression of IGF-1 and further improve pregnancy outcomes. Verifying the upstream and downstream mechanisms of IGF-1 at the maternal-fetal interface helps to find out more potential targets for the diagnosis and treatment of pregnancy-related diseases, and provide new ideas for the field.
