Research Progress on Chinese Herbal Medicine-derived Extracellular Vesicles in Wound Healing
10.13865/j.cnki.cjbmb.2025.05.1092
- VernacularTitle:中草药细胞外囊泡的分离提取及在创面修复中的作用
- Author:
Meng GENG
1
;
Yu-Ting LU
;
Hui SHI
Author Information
1. 江苏大学医学院,江苏省检验医学重点实验室,江苏,镇江 212000
- Publication Type:Journal Article
- Keywords:
chinese herbal medicine;
extracellular vesicles(EVs);
wound repair;
separation and isola-tion;
drug delivery
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(10):1489-1498
- CountryChina
- Language:Chinese
-
Abstract:
Wound healing is a dynamic physiological process involving haemostasis,inflammation,pro-liferation and tissue remodeling.Skin injuries,such as diabetic foot ulcers,venous ulcers,and pressure ulcers,are difficult to heal and impose a serious physical and psychological burden on patients,and tra-ditional treatments are difficult to address such problems.In recent years,Chinese herbal medicine-de-rived extracellular vesicles(CHMEVs)have shown promising potential in the field of wound repair and drug delivery due to their excellent biocompatibility,low immunogenicity and high safety.CHMEVs are nano-like particles enriched with herbal small molecule compounds,proteins and metabolites,and are a-ble to cross biological barriers and effectively regulate intercellular communication to promote tissue re-pair.In this review,the isolation and extraction methods of CHMEVs and their roles in wound repair are reviewed,and the prospects and challenges of their clinical applications are discussed.The combination of engineered modification and biomaterials of CHMEVs further expands their potential for application in precision medicine and provides a new idea for the treatment of hard-to-heal wounds in the future.
