O-glycosylation and DNA Damage Repair in Tumors
10.13865/j.cnki.cjbmb.2025.08.1127
- VernacularTitle:蛋白质O-糖基化与恶性肿瘤DNA损伤修复
- Author:
Wen-Qian LI
1
;
Jing-Ya GUO
;
Qing-Lei HANG
Author Information
1. 扬州大学医学部临床医学系,江苏扬州 225001
- Publication Type:Journal Article
- Keywords:
mucin-type O-glycosylation;
O-GlcNAcylation;
DNA damage;
tumorigenesis
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(10):1478-1488
- CountryChina
- Language:Chinese
-
Abstract:
O-glycosylation(including mucin-type O-glycosylation and O-GlcNAcylation),as a critical post-translational modification(PTM),regulates protein function,stability,and subcellular localization through the addition of glycan chains to serine or threonine residues,which participates in cellular signa-ling,metabolic regulation,and stress responses.DNA damage refers to the disruption of genomic integri-ty caused by endogenous factors(e.g.,metabolic byproducts,replication errors)or exogenous agents(e.g.,radiation,chemical substances),leading to carcinogenesis,aging,and genetic disorders.To counteract DNA lesions,organisms have evolved the DNA damage response(DDR)system,which or-chestrates complex protein networks to detect DNA damage and facilitate repair processes.Emerging evi-dence indicates that O-glycosylation can modulate DDR by influencing the activity,localization,and in-teractions of DNA repair-associated proteins.However,the precise mechanisms underlying O-glycosyla-tion-mediated DDR remain to be clarified.This review systematically summarizes:(1)the biosynthetic pathways of mucin-type O-glycosylation and O-GlcNAcylation,the cascade reactions in DDR;and(2)current research advances regarding O-glycosylation in tumor-associated DDR.Furthermore,we propose novel mechanistic perspectives and therapeutic strategies targeting O-glycosylation-mediated DDR dysreg-ulation in malignancies,aiming to provide a theoretical basis for tumor treatment.
