The Role and Clinical Prospects of Non-histone Lactylation in Tumor Progression
10.13865/j.cnki.cjbmb.2025.05.1081
- VernacularTitle:非组蛋白乳酰化修饰在肿瘤进展中的作用机制及临床前景
- Author:
Shao-Qiu DAI
1
;
Chen HUANG
1
;
Zai LUO
1
Author Information
1. 上海交通大学医学院附属第一人民医院胃肠外科,上海 200080
- Publication Type:Journal Article
- Keywords:
non-histone proteins;
lactylation modification;
lactate;
tumors
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(10):1499-1510
- CountryChina
- Language:Chinese
-
Abstract:
Lactylation modification is a new type of protein post-translational modification,which medi-ates the covalent binding of lactic acid groups to lysine residues through amide bonds,thus changing pro-tein function and intracellular signal transduction process.Lactylation modifications can be broadly cate-gorized into two types:histone lactylation and non-histone lactylation,both of which are dynamically and precisely regulated by the"Writer-Eraser"enzyme system.Among them,non-histone lactylation,mainly regulated by enzymes such as AARS1 and SIRT3,plays an important role in the progression of many dis-eases,including tumor metabolic reprogramming,ROS stress and signal pathway regulation.Especially in tumors,non-histone lactylation is closely related to tumor proliferation,immune escape and drug re-sistance.Therefore,an in-depth study of the role of non-histone lactylation in the progression of tumors is expected to provide new targets and strategies for the accurate diagnosis and treatment of tumors.It is noteworthy that in the context of non-histone lactylation modification,the interference effect of acetylation modification cannot be ignored.Lactylation and acetylation share similar"writer"and"eraser"enzymes and exhibit overlapping modification sites,suggesting the possibility of functional crosstalk between the two.Due to the current lack of specific editing tools targeting lysine lactylation,it remains challenging to definitively determine whether lactylation plays a predominant regulatory role.This article reviews the re-search progress of non-histone lactylation in tumors in recent years.
