Clinical Application of Botulinum Neurotoxins in Otolaryngology-head and Neck Surgical Diseases
10.13865/j.cnki.cjbmb.2025.09.1323
- VernacularTitle:肉毒杆菌神经毒素在耳鼻咽喉头颈外科疾病中的临床应用
- Author:
Jia-Qi WANG
1
;
Yi-Lin WU
;
Wei LI
Author Information
1. 中国医科大学附属第一医院耳鼻咽喉头颈外科,沈阳 110001
- Publication Type:Journal Article
- Keywords:
botulinum neurotoxin(BoNT);
head and neck dystonia;
migraine;
postoperative complica-tions of head and neck;
saliva management
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(10):1445-1456
- CountryChina
- Language:Chinese
-
Abstract:
The application of botulinum neurotoxin(BoNT)in cosmetic procedures of the head and neck is well established.In recent years,however,its therapeutic scope has significantly expanded to include functional and pathological disorders within this anatomical region.This article reviews the use of BoNT as an important treatment modality for various head and neck disorders,encompassing movement disor-ders(such as laryngeal,craniocervical,middle ear,oromandibular,and cervical dystonia),peripheral nerve dysfunction(including multiple system atrophy,migraine,synkinesis and spasm following facial nerve palsy),upper aerodigestive tract dysfunction(e.g.,post-laryngectomy complications,cricopharyn-geal dysphagia,pharyngeal pouch,and retrograde cricopharyngeal dysfunction),and autonomic nervous disorders(such as sialorrhea and gustatory sweating syndrome).By leveraging its highly specific neuro-modulatory effects,BoNT provides a reversible,minimally invasive,and potent therapeutic alternative for conditions often refractory to conventional pharmacological or surgical interventions.This review systemat-ically examines the mechanisms of action,injection techniques,clinical efficacy,and safety profiles of BoNT in the above-mentioned diseases,and discusses future applications,aiming to offer comprehensive evidence-based guidance for clinical practice to otolaryngologists-head and neck surgeons.
