Progress in role of B-cell receptors and their related signaling pathways in chronic lymphocytic leukemia
10.3969/j.issn.1000-4718.2025.09.021
- VernacularTitle:B细胞受体及其相关信号通路在慢性淋巴细胞白血病中的研究进展
- Author:
Xiangli WANG
1
;
Sirui TIAN
1
;
Tao WU
1
Author Information
1. 甘肃中医药大学第一临床医学院,甘肃 兰州 730000;中国人民解放军联勤保障部队第九四〇医院全军血液病中心,甘肃 兰州 730050
- Publication Type:Journal Article
- Keywords:
chronic lymphocytic leukemia;
B-cell receptor;
signal transduction
- From:
Chinese Journal of Pathophysiology
2025;41(9):1847-1854
- CountryChina
- Language:Chinese
-
Abstract:
Chronic lymphocytic leukemia(CLL)is a mature B-lymphocyte proliferative tumor with significant heterogeneity.Studies have demonstrated that aberrant activation of the B-cell receptor(BCR)signaling pathway repre-sents the central mechanism underlying CLL.In recent years,inhibitors targeting the BCR signaling pathway have marked-ly improved the prognosis of patients with CLL.This review summarizes the specific roles and clinical applications of the BCR and its associated signaling pathways in CLL pathogenesis,describes how BCR modulates the tumor microenviron-ment,and delineates the metabolic reprogramming mediated by BCR signaling.
