Meta-analysis on the prevalence of low-level viraemia in Chinese patients receiving antiviral therapy for HIV infection
10.12138/j.issn.1671-9638.20256876
- VernacularTitle:中国HIV感染抗病毒治疗患者低病毒血症患病率Meta分析
- Author:
Tingyu YANG
1
;
Xuemei AN
;
Long LI
;
Linyu HUANG
;
Xingling ZHANG
;
Zhongxi HONG
Author Information
1. 成都中医药大学护理学院,成都 610000
- Publication Type:Journal Article
- Keywords:
acquired immunodeficiency syndrome;
antiviral therapy;
prevalence;
Meta-analysis
- From:
Chinese Journal of Infection Control
2025;24(10):1470-1477
- CountryChina
- Language:Chinese
-
Abstract:
Objective To comprehensively evaluate the prevalence of and influencing factors for low-level viraemia(LLV)in Chinese patients receiving antiviral therapy for human immunodeficiency virus(HIV)infection through systematic review and Meta-analysis.Methods Cochrane Library,Web of Science,Embase,PubMed,China Bio-medicine(CBM),VIP,China National Knowledge Infrastructure(CNKI),and Wanfang Data were systematically retrieved.Retrieval time was from the establishment of the database to February 2024.Literatures related to the prevalence of LLV in patients receiving antiviral therapy for HIV infection were retrieved using combination of key-words and free words.Stata 16.0 software was used for Meta-analysis.Random effects model was adopted to calcu-late the combined prevalence and its 95％confidence interval.Results A total of 15 papers were included in analy-sis,involving 191 212 specimens.Meta-analysis random effects model showed that the prevalence of LLV in Chinese patients receiving antiviral therapy for HIV infection was 13.00％(95％CI:7.82％-19.24％).Subgroup analysis showed that cross-sectional studies,northern regions,males,age ≥50 years,heterosexual transmission routes,baseline CD4+T lymphocyte count＜200 cells/μL,and patients who had ever changed therapy regimens had higher LLV prevalence.Conclusion The prevalence of LLV in patients receiving antiviral therapy for HIV infection is re-latively higher.Attention should be paid to such high-risk population,and appropriate antiviral therapy schemes should be selected as early as possible.Timely intervention is necessary when LLV occurs.
