Advances in role and drug treatment of endoplasmic reticulum stress in rheumatoid arthritis
10.3969/j.issn.1000-4718.2025.00.009
- VernacularTitle:内质网应激在类风湿关节炎中的作用及药物治疗的研究进展
- Author:
Yuru WANG
1
;
Yumeng ZHANG
1
;
Yang LIU
1
;
Huiqin HAO
1
Author Information
1. 山西中医药大学中西医结合基础实验室,山西 晋中 030619
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
endoplasmic reticulum stress;
unfolded protein response
- From:
Chinese Journal of Pathophysiology
2025;41(9):1839-1846
- CountryChina
- Language:Chinese
-
Abstract:
Endoplasmic reticulum stress(ERS)plays a crucial role in cellular self-protection.In response to environmental changes,cells activate the unfolded protein response(UPR)and endoplasmic reticulum-associated protein degradation pathways to restore homeostasis.Increasing experimental evidence indicates that hypoxia and inflammation negatively impact synoviocytes in rheumatoid arthritis(RA),leading to the activation of three key endoplasmic reticulum transmembrane proteins:inositol-requiring enzyme 1,protein kinase R-like endoplasmic reticulum kinase,and activating transcription factor 6.These proteins mediate UPR pathways that are implicated in the pathological progression of RA.Targeting ERS-related molecules has emerged as a promising therapeutic strategy for RA.This article reviews the impact of ERS on the pathogenesis of RA and discusses drugs that modulate ERS as potential treatments for the disease.
