Progress in mechanism of quercetin alleviating nonalcoholic fatty liver disease
10.3969/j.issn.1000-4718.2025.09.019
- VernacularTitle:槲皮素缓解非酒精性脂肪性肝病作用机制的研究进展
- Author:
Lianghao LIU
1
;
Qingliang SONG
;
Maoxing PAN
;
Yupei ZHANG
Author Information
1. 暨南大学中医学院,广东 广州 510632
- Publication Type:Journal Article
- Keywords:
quercetin;
nonalcoholic fatty liver disease;
pharmacokinetics;
mechanism of action
- From:
Chinese Journal of Pathophysiology
2025;41(9):1832-1838
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease(NAFLD)is the chronic liver disease with the highest global preva-lence.It has multiple causes and complex mechanisms,and its prevalence is increasing year by year.Currently,there are still no drugs that are widely promoted and used.Quercetin possesses multiple pharmacological activities such as antioxida-tion,anti-inflammation,lipid-lowering and regulation of intestinal flora.Recent studies have shown that it can intervene in the progression of NAFLD through multiple pathways,including anti-inflammation,promotion of autophagy,inhibition of oxidative stress,attenuation of insulin resistance,regulation of endoplasmic reticulum stress and improvement of cogni-tion.In addition,quercetin can also inhibit diabetes mellitus complicated with NAFLD lesions.This article reviews the mechanism by which quercetin alleviates NAFLD,with the aim of providing a reference for the clinical prevention and treatment of NAFLD.
