Research progress on the effects of assisted reproductive technology on the risk of offspring developmental glycolipid metabolic disease
10.3760/cma.j.cn101441-20221012-00449
- VernacularTitle:辅助生殖技术对子代发育源性糖脂代谢病发生风险影响的研究进展
- Author:
Jiani JIN
1
;
Ruixue CHEN
1
;
Dan ZHANG
1
Author Information
1. 生殖遗传教育部重点实验室 浙江大学医学院附属妇产科医院，杭州 310000
- Publication Type:Journal Article
- Keywords:
Reproductive techniques, assisted;
Obesity;
Glycolipid metabolic diseases;
Developmental origins of diseases;
Epigenetic inheritance
- From:
Chinese Journal of Reproduction and Contraception
2023;43(6):599-605
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, assisted reproductive technology (ART) has become an integral part of modern medicine and now plays a key role in population growth. Although ART has solved the problem of "no child" among some infertile couples, the short-term and long-term health outcomes of offspring conceived by ART is still controversial due to its non-physiological operating conditions. It has been found that the key procedures of ART may increase offspring's risk of developmental glycolipid metabolic disease by resetting epigenetic memory in gamete and embryo early development. This article systematically described the effects of controlled ovulation hyperstimulation, in vitro embryo culture, in vitro oocyte maturation, intracytoplasmic sperm injection, embryo cryopreservation and preimplantation genetic testing on offspring's risk of developmental glycolipid metabolic diseases, to provide new ideas for confirming offspring safety and improving the therapeutic strategy of assisted reproduction
