Effects of endometrial thickness compaction after progesterone addition on pregnancy outcomes after frozen-thawed cleavage embryo transfer cycles
10.3760/cma.j.cn101441-20220813-00347
- VernacularTitle:人工周期孕酮添加后子宫内膜厚度紧缩对冻融卵裂期胚胎移植后妊娠结局的影响
- Author:
Xiaoli CHEN
1
;
Ningning WANG
1
;
Shiming WANG
1
;
Bo SUN
1
;
Yingchun SU
1
Author Information
1. 郑州大学第一附属医院生殖医学中心，郑州 450052
- Publication Type:Journal Article
- Keywords:
Embryo transfer;
Pregnancy outcome;
Cleavage embryo;
Endometrial compaction
- From:
Chinese Journal of Reproduction and Contraception
2023;43(9):919-925
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of endometrial thickness compaction after administration of progesterone on pregnancy outcomes of frozen-thawed cleavage embryo transfer patients.Methods:In this retrospective cohort study, the clinical data of 1 173 patients who received the first frozen-thawed cycle with cleavage embryo transfer in Center for Reproductive Medicine of the First Affiliated Hospital of Zhengzhou University from July 1, 2015 to March 1, 2021 were retrospectively analyzed. The patients with endometrial thickness decreased by ≥5% on the day of transplantation compared with the day progesterone added was designated as the compaction group (181 cases), and the remaining patients were in the non-compacted group (992 cases). Clinical pregnancy rate, ongoing pregnancy rate, and live birth rate were compared between the two groups.Results:The clinical pregnancy rate [36.46% (66/181)] and the ongoing pregnancy rate [34.25% (62/181)] of the patients in the compaction group were lower than those in the non-compacted group [48.99% (486/992), P=0.002; 42.34% (420/992), P=0.043]. In addition, the live birth rate in the compaction group [32.66% (59/181)] was lower than that in the non-compacted group [39.62% (393/992)], although not statistically significant ( P=0.075). We used the multivariate regression model to correct confounding factors. The final model showed that endometrial compaction was inversely associated with clinical pregnancy (a OR=0.578, 95% CI: 0.412-0.811, P=0.002) and ongoing pregnancy (a OR=0.685, 95% CI: 0.485-0.967, P=0.031). Conclusion:The compaction of endometrial thickness after the addition of progesterone is not conducive to the acquisition and maintenance of pregnancy in patients with cleavage embryo transfer. Based on the research's conclusions, we suggest that patients should timely detect the endometrial thickness after progesterone addition during the thaw cycle with cleavage embryo transferred.
