Advances in bladder cancer treatment:chemicobiology-driven innovative therapeutic strategies
10.3969/j.issn.1009-8291.2025.10.014
- VernacularTitle:膀胱癌治疗研究进展:化学生物学驱动的创新治疗策略
- Author:
Huiyu CHEN
1
;
Xin WANG
;
Qing ZHANG
;
Ran XIE
;
Hongqian GUO
Author Information
1. 南京大学医学院附属鼓楼医院泌尿外科,江苏南京 210008
- Publication Type:Journal Article
- Keywords:
bladder cancer;
chemical modification;
targeted therapy;
drug delivery;
gene therapy;
photodynamic therapy;
sonodynamic therapy;
chemodynamic therapy
- From:
Journal of Modern Urology
2025;30(10):895-902
- CountryChina
- Language:Chinese
-
Abstract:
This article highlights the limitations of traditional treatment methods for non-muscle-invasive bladder cancer and the multi-dimensional exploration of emerging strategies.It firsty reviews the history and challenges of BCG immunotherapy,pointing out its bottlenecks in efficacy,tolerance,and supply,and focuses on its chemicobiological modifications,such as the optimization of nanoparticle drug delivery systems and immune-active components.Subsequently,it summarizes the development of various new treatment approaches,including gene therapy,photodynamic/sonodynamic therapy,chemodynamic therapy,and proteolysis-targeting chimeras for targeted protein degradation strategies.It particularly emphasizes the enhancement of drug delivery efficiency and targeting in the bladder through nanotechnology,aptamer-mediated systems,and biomimetic carriers.The treatment of bladder cancer is gradually transforming from local and single-mode to precise,synergistic,and low-toxicity directions,with chemicobiological means playing a core role in driving this transformation.Interdisciplinary integration provides a broad space and new hope for the treatment of bladder cancer.
