Research progress and application of human endometrium organoids
10.3760/cma.j.cn101441-20220518-00219
- VernacularTitle:人子宫内膜类器官的研究进展及应用
- Author:
Wenwen LI
1
;
Qiong XING
1
;
Chao WANG
1
;
Zhaolian WEI
1
;
Jianye WANG
1
Author Information
1. 安徽医科大学第一附属医院妇产科生殖中心，合肥 230022
- Publication Type:Journal Article
- Keywords:
Endometrium;
Organoids;
Three-dimensional culture;
Gynecologic diseases;
Drug screening;
Personalized medicine;
Regenerative medicine
- From:
Chinese Journal of Reproduction and Contraception
2023;43(8):842-846
- CountryChina
- Language:Chinese
-
Abstract:
Endometrium organoids (EOs) are formed three-dimensional culture by self-organizing stem cells, which is similar to the endometrium in structure and function. EOs remain the biological characteristics of the original tissue and maintain gene stability, which are ideal research model to simulate the physiological structure and function of the endometrium in vitro. With the development of biotechnology and organoid culture methods, EOs can be used not only in endometrial development research, but also in gynecological disease models, drug screening, personalized diagnosis and treatment, and regenerative medicine. In order to popularize the EOs for the basic and clinical research, this review summarizd the research progress and application prospects of EOs.
