Research progress of retrotransposon LINE-1 mediating abnormal gamete and embryo development
10.3760/cma.j.cn101441-20220318-00119
- VernacularTitle:逆转录转座子LINE-1介导配子和胚胎发育异常的研究进展
- Author:
Yunlu PING
1
;
Xiaoxuan ZHAO
;
Xiaoling FENG
Author Information
1. 黑龙江中医药大学研究生院，哈尔滨 150040
- Publication Type:Journal Article
- Keywords:
Embryonic development;
Gametogenesis;
Retrotransposon;
Long interspersed nuclear element-1;
Early spontaneous abortion
- From:
Chinese Journal of Reproduction and Contraception
2023;43(7):757-762
- CountryChina
- Language:Chinese
-
Abstract:
Long interspersed nuclear element-1 (LINE-1) is the only self-transposable non-terminal repeat retrotransposon in the human genome, which can copy and paste to new sites in the genome. To ensure evolutionary success, heritable new LINE-1 inserts accumulate in germ cells and embryonic stem cells, which carry genetic information. However, the reduction of LINE-1 inhibition in early embryo development may lead to genomic mutations induced by reverse transposon insertion. Increased LINE-1 mRNA and protein expression may indirectly cause early embryo damage or even pregnancy loss by inducing oocyte wear, DNA damage and immune inflammatory response. This paper summarized and analyzed the research progress on the role of LINE-1 epigenetic regulation in gametogenesis and early embryo development and the causes of early pregnancy loss.
