Effects of different body mass index on perinatal and neonatal outcomes of frozen-thawed embryo transfer in PCOS patients
10.3760/cma.j.cn101441-20211011-00455
- VernacularTitle:不同体质量指数对PCOS患者冻融胚胎移植围产结局及新生儿结局的影响
- Author:
Guiying LUO
1
;
Jingxian CHENG
1
;
Chunyan WANG
1
;
Jieyu WANG
1
;
Lanlan YUAN
1
;
Linlin SONG
1
;
Xuanye WU
1
;
Yunxia CAO
1
Author Information
1. 安徽医科大学第一附属医院生殖中心，合肥 230032
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Body mass index;
Frozen-thawed embryo transfer;
Perinatal outcome;
Neonatal outcome
- From:
Chinese Journal of Reproduction and Contraception
2023;43(1):57-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of polycystic ovary syndrome (PCOS) patients with different body mass index (BMI) on perinatal and neonatal outcomes of frozen-thawed embryo transfer.Methods:A retrospective cohort study was performed on the clinical data of patients with PCOS infertility who underwent cryopreservation transplantation in Reproductive Center of the First Affiliated Hospital of Anhui Medical University from 2016 to 2020. The clinical pregnancy was singleton, a total of 1 481 cycles were divided into 4 groups according to BMI value. There were 75 cycles in the underweight group (BMI<18.5 kg/m 2), 793 cycles in the normal weight group (18.5 kg/m 2≤BMI<24.0 kg/m 2), 468 cycles in the overweight group (24.0 kg/m 2≤BMI<28.0 kg/m 2), 145 cycles in the obese group (BMI≥28.0 kg/m 2). The differences of general information, perinatal outcome and neonatal outcome were compared among the four groups. Results:Compared with the overweight group, the normal weight group and the underweight group, the obesity group had the highest early abortion rate [23.4% (34/145) vs. 15.8% (74/468) vs. 14.0% (111/793) vs. 9.3% (7/75), P=0.014], and the lowest live birth rate [68.3% (99/145) vs. 76.7% (359/468) vs. 79.7% (632/793) vs. 88.0% (66/75), P=0.003]. The incidence of gestational diabetes in the obesity group and the overweight group [6.9% (10/145) and 4.5% (21/468)] was higher than that in the normal weight group [2.3% (18/793)] (the obesity group vs. the normal weight group P=0.005, the overweight group vs. the normal weight group P=0.028). The rate of cesarean section in the obesity group and the overweight group [81.8% (81/99), 74.9% (269/359)] was higher than that in the normal weight group [67.6% (427/632)] and the underweight group [57.6% (38/66), the obesity group vs. the normal weight group P=0.005, the obesity group vs. the underweight group P=0.001, the overweight group vs. the normal weight group P=0.015, the overweight group vs. the underweight group P=0.004]. The macrosomia birth rate [18.2% (18/99), 15.6% (56/359)] was also higher than that of the normal weight group [10.1% (64/632)] and the underweight group [6.1% (4/66), the obesity group vs. the normal weight group P=0.018, the obesity group vs. the underweight group P=0.025, the overweight group vs. the normal weight group P=0.011, the overweight group vs. the underweight group P=0.041]. There were no significant differences in late abortion rate, gestational hypertension, ectopic pregnancy and premature birth rate, Apgar score, height and birth defects (all P>0.05). Conclusion:Obesity and overweight affect the perinatal outcomes and neonatal outcomes in patients with PCOS. In clinical work, attention should be paid to the weight management of PCOS patients.
