Wound infection caused by Mycobacterium senegalense:one case report and literature review
10.16718/j.1009-7708.2025.05.010
- VernacularTitle:塞内加尔分枝杆菌伤口感染1例并文献复习
- Author:
Xiaohui WANG
1
;
Xuzhu MA
;
Dan LEI
;
Minggui LIN
Author Information
1. 清华大学附属北京清华长庚医院感染性疾病科,清华大学临床医学院,北京 102218
- Publication Type:Journal Article
- Keywords:
Mycobacterium senegalense;
rapidly growing nontuberculous Mycobacterium;
infection
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(5):540-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical features,diagnosis,and treatment of Mycobacterium senegalense infection.Methods We reported a case of postoperative wound infection caused by M.senegalense in a patient who underwent spinal intradural tumor surgery at Beijing Tsinghua Changgung Hospital.CNKI,Wanfang,VIP,and PubMed databases were searched from inception to April 1,2024 using keywords Mycobacterium senegalense both in Chinese and English to identify relevant reports.Thirteen eligible articles were retrieved,including 1 in Chinese and 12 in English.The clinical data of the 13 cases of M.senegalense infection were reviewed and analyzed.Results A case of postoperative wound infection caused by M.senegalense was reported in a patient who underwent spinal intradural tumor surgery.The patient was a 53-year-old male.He was previously healthy.The patient was initially treated for schwannoma by resection of an intraspinal space-occupying lesion at another hospital.Two weeks after the operation,the skin surrounding the surgical incision became redness,swelling,and pain.The patient did not have fever.M.senegalense was identified from pus culture.The patient was treated with doxycycline,moxifloxacin,and clarithromycin combination therapy,as well as wound disinfection and dressing changes.The infected wound subsequently healed.Among the 13 patients with M.senegalense infection,30.8％(4/13)were males and 69.2％(9/13)were females.The average age of patients was(51.6±17.7)years.The reported cases included skin and soft tissue infection(7 cases),bloodstream infection(2 cases),artificial joint infection(2 cases),and one case each of osteomyelitis and prosthetic infection.About half(46.2％,6/13)of the patients were immunosuppressed.Most(76.9％,10/13)of the patients were infected after surgery and trauma.Antimicrobial susceptibility test showed that all of the M.senegalense isolates were susceptible to amikacin,ciprofloxacin,clarithromycin and doxycycline.Conclusions M.senegalense infection is rarely reported.It primarily occurs following surgical procedures or trauma.Appropriate and adequate antibiotic combination therapy based on antimicrobial susceptibility testing generally results in favorable outcomes.
