Pneumonia caused by Rhizopus microsporus:a case report and literature review
10.16718/j.1009-7708.2025.05.009
- VernacularTitle:毛霉肺炎1例并文献复习
- Author:
Jinmei YANG
1
;
Ruifang YANG
1
;
Ailing WANG
1
;
Jipeng SUN
1
;
Wenting YI
1
;
Qiaoli YU
1
;
Jiankai FENG
1
Author Information
1. 滨州医学院烟台附属医院检验科,山东烟台 264000
- Publication Type:Journal Article
- Keywords:
Rhizopus microsporus;
infection;
mucormycosis;
pneumonia
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(5):535-539
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review the characteristics of Rhizopus microsporus infection for better awareness of the disease.Methods One case of pneumonia caused by R.microsporus was reported in a 66-year-old male patient.Similar reports on infections caused by R.microsporus were retrieved in PubMed and CNKI databases since 2013.The characteristics of patients with R.microsporus infection were reviewed.Results This case involves a 66-year-old male patient presenting with a 10-day history of cough,sputum production,and hemoptysis.The patient had a previous history of diabetes mellitus.Pulmonary CT scan revealed an irregular soft tissue density mass in the right lower lobe and pneumonia.The clinical presentation and laboratory findings were consistent with pulmonary mucormycosis caused by R.microsporus.R.microsporus was isolated from bronchoalveolar lavage fluid culture.The patient was treated with intravenous liposomal amphotericin B followed by oral posaconazole for antifungal therapy,and achieved a favorable prognosis.A total of 24 cases(18 males,5 females,1 unknown)of R.microsporus infection were reviewed(including this one).The specific site of infection included pulmonary infection(n=10),ocular infection(n=1),skin tuberculosis(n=1),splenic abscess(n=1),oral mucositis(n=1),gouty arthritis(n=1),esophageal ulceration(n=1),abdominal infection(n=1),and others(n=7).The clinical symptoms varied with the organs involved.Majority of the patients(n=11)were cured by surgery combined with antimicrobial therapy.Overall,13 patients died.Conclusions Clinicians should be aware of the possibility of R.microsporus infection in case of pulmonary infection,especially those with diabetes mellitus.
