Survival analysis of HIV-infected patients complicated with progressive multifocal leukoencephalopathy
10.16718/j.1009-7708.2025.05.006
- VernacularTitle:人类免疫缺陷病毒感染合并进行性多灶性脑白质病患者的生存分析
- Author:
Honghong YANG
1
;
Jing YUAN
1
;
Mei LI
1
;
Qin ZENG
1
;
Yushan WU
1
;
Min LIU
1
Author Information
1. 重庆市公共卫生医疗救治中心感染科,重庆 400036
- Publication Type:Journal Article
- Keywords:
human immunodeficiency virus;
progressive multifocal leukoencephalopathy;
survival rate;
CD4+T cell count;
modified Rankin scale
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(5):517-522
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mortality and risk factors of HIV-infected patients complicated with progressive multifocal leukoencephalopathy(PML)to inform the outcomes of these patients.Methods The clinical data of people living with HIV related PML who were treated at Chongqing Public Health Medical Treatment Center from January 1,2019 to December 31,2023 were retrospectively analyzed.Kaplan-Meier method was used for survival analysis.Log-rank test was performed.Cox regression model was used for multivariate analysis.Results A total of 42 people living with HIV related PML were enrolled,including 34 males(81.0％).The median age was 44.5(36.3,51.0)years.PML was confirmed in 76.2％(32/42)of patients,and possible PML was diagnosed in 23.8％(10/42)of patients.The median time to diagnosis was 32.5(14.8,58.3)days.The median CD4+T cell count was 69.0(39.8,112.0)cells/μL.The median HIV viral load was 5.05(2.62,5.77)log10 copies/mL.The overall mortality rate was 54.8％(23/42)for patients with HIV related PML.CD4+T cell count ≤50 cells/μL and initial modified Rankin scale(mRS)score ≥4 points were independent risk factors for the overall mortality of people living with HIV related PML(P＜0.05).Conclusions People living with HIV related PML have a high mortality rate.Low CD4+T cell count and high initial mRS score were independent risk factors for the mortality of patients with HIV related PML.Currently,no definitive and effective drug treatment is available for PML.Early detection,diagnosis and initiation of antiretroviral therapy may improve the outcomes of patients.
