Effects of C-Reactive Protein and Fibrinogen on Activated Partial Thromboplastin Time and Anti Xa Activity in Extracorporeal Membrane Oxygenation Patients
10.13241/j.cnki.pmb.2025.15.017
- VernacularTitle:C反应蛋白、纤维蛋白原对体外膜肺氧合患者活化部分凝血活酶时间、抗Xa活性的影响
- Author:
Jing-shu FANG
1
;
Fang-yan GAN
1
;
Shuang DENG
1
Author Information
1. 广西壮族自治区人民医院检验科 广西南宁 530021
- Publication Type:Journal Article
- Keywords:
Extracorporeal membrane oxygenation;
C-reactive protein;
Fibrinogen;
Activated partial thromboplastin time;
Anti Xa activity
- From:
Progress in Modern Biomedicine
2025;25(15):2524-2529
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of C-reactive protein(CRP)and fibrinogen(FIB)on activated partial thromboplastin time(APTT)and anti Xa activity in extracorporeal membrane oxygenation(ECMO)patients.Methods:The clinical data of 33 patients undergoing ECMO support treatment at Guangxi Zhuang Autonomous Region People's Hospital from January 2024 to July 2024 were retrospective analysis.Patients undergoing ECMO support treatment were divided into low-CRP group and high-CRP group.FIB,APTT and anti-Xa activity between low-CRP group and high-CRP group were compared.The correlation between APTT and anti-Xa activity in low-CRP group and high-CRP group were analyzed by Pearson method.Results:The APTT levels in the high CRP group was higher than that in the low CRP group(P＜0.05).There was no statistically significant difference in anti Xa activity between the low CRP group and the high CRP group(P＞0.05).The FIB levels in the high CRP group was higher than that in the low CRP group(P＜0.05).The correlation between APTT and anti-Xa activity in the low-CRP group was positively correlated(r=0.698,P＜0.05),while the correlation between APTT and anti-Xa activity in the high-CRP group was positively correlated(r=0.650,P＜0.05),there was no strong in the correlation between APTT and anti-Xa activity between the low-CRP group and high-CRP group.Conclusion:Abnormal elevation of CRP levels can affect the detection of APTT in patients undergoing ECMO supportive therapy,but does not affect the detection of anti-Xa activity.The correlation between APTT and anti-Xa activity is not strong,so multiple monitoring indicators should be combined to comprehensively evaluate the anticoagulant efficacy of heparin.
